I’m sure it’s something that’s crossed your mind, when you consider making the switch from T4-only medication like Levothyroxine, to Natural Desiccated Thyroid;
If it’s so good at treating hypothyroidism, why won’t my doctor prescribe it for me?
It crossed mine, and I did a lot of research in to the answers. I’m going to share what I found out about the history of NDT, below.
A pig’s thyroid gland closely resembles the human thyroid gland, therefore it provides the multiple components missing in hypothyroid patients when their thyroids start going haywire; T1, T2, T3, T4 and Calcitonin.
T4 is the storage hormone, and T3 the most active.
Thyroid Pharmacist, Isabella Wentz, explains that the standards of testing the level of hormones in NDT in its early days, were nowhere near today’s standards, so this sometimes resulted in inaccurate dosing. Doses were compounded and apparently any pharmacist could put an amount into a capsule, so this was not always an accurate process. The scale they used was not very sensitive, either.
Today’s standards for compounding have changed, with more-sensitive scales used, by specially trained pharmacists, in specially certified compounding pharmacies.
In the 1950-60’s, pharmaceutical companies noticed that doctors were frustrated with inconsistent results from the above mentioned process, so they created a more predictable product that was more reliable (and that they could make some money out of, not forgetting); isolated T4.
T4 is the thyroid hormone produced in the highest amount (about 90%) out of all five thyroid hormones mentioned above.
Manufacturers of T4-only meds claimed that patients taking T4 on its own, could convert the T4 into some T3, which is the second most needed thyroid hormone (about 9% of all that is produced) and it is essential in feeling well. T3 is the active hormone; Hypothyroid Mom covers its importance here. The other three thyroid hormones produced, t1, T2 and Calcitonin, are only produced and needed in very tiny amounts. So, taking isolated T4 makes sense in theory, if it’s going to convert in to T3. (The generic name for T4-only drugs is Thyroxine, Levothyroxine, Synthroid etc. and this is what most patients know it as.)
But a lot of people always have and always will struggle to convert T4 in to T3. And the body isn’t meant to live on T4, a storage hormone, alone.
But T4-only medicine was not the only medication with improved predictability at this time, as eventually, NDT’s dosage variability was addressed too, but by that time, it had fallen out of favor.
The pharmaceutical companies went on to patent their T4-only drug brand names, so this is where we can start to suspect that money was a big factor in NDT’s decline, as NDT comes from a natural (animal) source, so cannot be patented.
So imagine if our doctors began prescribing NDT over the patented T4-only medications. Those pharmaceutical companies wouldn’t profit, would they?
Women Living Naturally have this to say about natural medicine for Oestrogen Dominance:
But if it’s so wonderful then why don’t you hear more about it?
The answer is easy! The pharmaceutical companies can not make big bucks on a herb that is chemical free. No chemical processes then no patent. When pharmaceutical companies can patent a drug it becomes exclusive with a price that they set. The pharmaceutical companies would rather process products that create nasty side effects, fund studies that support these products then they sell another drug to combat the side effects of the first and so on. The results: A damaging viscous downward cycle of health.
Although a different condition (which does often come hand in hand with thyroid conditions), the point still stands. Pharmaceutical companies make more money on synthetic products. NDT is natural and cannot be patented.
STTM explain that at the time of this, a lot of false claims were also circulating, regarding how ‘unsafe’ NDT apparently was.. what a coincidence! It’s suspected that these claims could have been started by the pharmaceutical companies and doctors backing the switch to T4-only meds and myself and others wonder if they were (possibly still are?) receiving incentives for prescribing T4-only meds, from big pharma. The false claims about NDT were later confirmed to be a hoax, but by the time this was identified, the damage to NDT had been done, and T4-only meds were now the drug of choice. Some doctors these days still believe these false claims, and claim NDT to be unsafe or inconsistent. It’s what doctor after doctor has said to me. Patients who use it completely disagree. Of course, it matters where you source it from. You want to make sure it is a reputable source, and you’re getting what you pay for and you need to dose it responsibly.
Mary Shomon also explains that the makers of T4-only medication such as Synthroid for example, have sponsored medical meetings, golf outings, symposia, research grants, and speakers’ fees, and have provided free patient literature, pens, pads, mugs, and other giveaways and marketing items. So the doctor’s prescribing it have things to gain don’t they? Alternatively, they also have a lot to lose if they don’t..
Given the amount of people with hypothyroidism, this newly created T4-only medicine gave pharmaceutical companies a big opportunity to make quite a bit of money, but it appears to be at the expense of the thyroid patients taking it, and still feeling unwell. Millions of thyroid patients have been left with little to no quality of life, due to T4-only drugs not being what works for them, and doctors refusing to look at the bigger picture of treating patients based on their own individual needs and requirements. Some people do just fine on T4-only meds, for some it helps them part-way, and for others, not at all.
Since the invention and push of T4-only meds, new doctors are mostly being taught to prescribe T4- only meds and nothing else. Doctors now claim NDT is outdated and less reliable than T4-only meds, despite there being many thyroid patients who claim that T4-only brands like Levothyroxine, fail to properly treat their hypothyroidism and symptoms; like me. And many claim NDT works better for them. Like me.
Isabella Wentz explains that the 1980’s also cast T3 in a negative light, when weight loss clinics started prescribing T3 for people without thyroid disease (creating hyperthyroidism in the users) to encourage weight loss. As a result, patients were admitted to hospital with dangerous symptoms of hyperthyroidism. So you can see why many endocrinologists and doctors today have an aversion to T3 or T4 and T3 combination medicine, for hypothyroidism. However, it’s not fair on the patients who do need it to feel better today, and it can be used safely and effectively.
As recently as late 2012, the Clinical Practice Guidelines for Hypothyroidism in Adults — published by the American Association of Clinical Endocrinologists (AACE) and the American Thyroid Association (ATA) misrepresented natural desiccated thyroid. It summarized the concerns with the Guideline’s discussion of natural thyroid in this editorial, but basically, they continued to suggest that there were prescription drugs of bovine (cow) origin -there aren’t – and tried to close the subject by saying “There is no evidence to support using desiccated thyroid hormone in preference to L-thyroxine monotherapy in treating hypothyroidism and therefore desiccated thyroid hormone should not be used for the treatment of hypothyroidism.” What did they fail to mention? There is no evidence to support using levothyroxine in preference to natural desiccated thyroid. The research simply hadn’t been done either way..
Interestingly, the ATA’s survey results of over 12,000 people published in May 2018 has since contradicted this. It says:
The survey demonstrated a distinct subset of patients who are dissatisfied with their therapies and their physicians. On a scale from 1 to 10, overall degree of satisfaction with therapy was rated 5. How much hypothyroidism has affected their lives received a score of 10.
Second, patients taking natural preparations, rather than synthetic hormone replacement therapy or combination therapy, were more satisfied with their treatment. DTE (animal-derived natural thyroid preparations or desiccated thyroid extract) was the original form of treatment and received a satisfaction score of 7. DTE was widely replaced in the 1960s when L-T4 (levothyroxine, a synthetic hormone replacement therapy) could be mass-produced inexpensively; its patients gave it a score of 5. The combination therapy of L-T4 along with synthetic T3 (liothyronine or cytomel) received a satisfaction score of 6. Patients taking DTE were less likely to report problems with weight management, fatigue/energy levels, mood, and memory compared to those taking either the L-T4 monotherapy or the combination therapy.
A another study conducted by Thanh D. Hoand, DO, who presented his research at the Endocrine Society Annual Meeting in June 2013, backs up the positive effects of treating hypothyroidism with NDT. Dr. Hoang’s research proved that NDT is a viable alternative to Levothyroxine. Almost half, 49%, of the seventy patients involved in the study preferred NDT treatment compared to just 19% of patients who preferred Levothyroxine.
When I was on Levothyroxine, I saw no relief or improvement of my symptoms, and I only gained more and more symptoms. When I decided to make that big jump myself, to NDT, I started getting better.
Hypothyroid Mom interestingly states:
A list of the 25 most prescribed drugs in 2011 was released in a report by the IMS Institute of Healthcare Informatics. Levothyroxine was listed the SECOND MOST-PRESCRIBED DRUG in the U.S., with 104.7 million prescriptions in 2011.1
Granted, this is an American source, but if doctors stop prescribing T4-only meds, those pharmaceutical companies we were talking about have a lot to lose, don’t they?
You’re no doubt starting to see why money is a big factor behind thyroid medication and why doctors favour isolated T4.
This whole situation makes me frustrated. It makes me angry. It upsets me that so many people out there, living with hypothyroidism, are receiving a sub-standard quality of treatment, because of this. Many patients don’t even realise they’re inadequately treated. They’re also diagnosed with Depression, Fibromyalgia, Chronic Fatigue Syndrome, Acid Reflux/GERD/GORD, amongst many other things and they think they have all these separate conditions, when in reality, they could well be being caused by an inadequately treated thyroid problem, and not being on the medicine right for their needs.
My acid reflux, depression, hormonal migraines and chronic fatigue all went after a being on NDT for a while. I now just take my NDT each day and I need no other medicine. No antidepressants or anti-anxiety meds, no acid reflux meds, no pain killers.
If you don’t feel well on T4-only medicine such as Levothyroxine and Synthroid (to name just two), or have been diagnosed with more than just an underactive thyroid, or you have other symptoms or ailments, maybe a doctor hasn’t even taken seriously, please get a full thyroid panel blood test done, and check your thyroid levels. Most importantly, your Free T3 and Free T4, although Reverse T3, TPOAB and TGAB are also very beneficial to test.
You may just do better on another thyroid medication. (I would always suggest working with a doctor to make any change to your health regime.)
You can click on the hyperlinks in the above post to learn more and see references to information given, but more reading and references can also be found at:
Rachel, The Invisible Hypothyroidism
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